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1 mmol kg body weight of gadopentetate dimeglumide contrast media was power injected at 2 mL sec, followed by a saline chase of 20 mL at a rate of 2 mL sec. Then, MRP acquisition was performed. A series of cor onal T1 weighted three dimensional volume interpolated excitation images were obtained after 5 second delay after the INNO-406 臨床試験 initiation of contrast media injection, and the scanning continued for up to 4 minutes and 40 sec onds. The acquisition parameters included: TR 5 msec, TE 1. 58 msec, 5 mm slice thickness, 0 mm interslice gap, 20 slices, 123 × 192 matrix, 15 degree flip angle, and field of view of 400 × 400 mm. Two consecutive 7 second acqui sitions forming two different time points were repeated 10 times with a delay of 14 seconds between them.

The scan ning time Lapatinib 構造 in every acquisition was 14 seconds with a break of 14 seconds, and the patients were asked to hold their breath during acquisition. Finally, delayed postcontrast T1 weighted images were taken as follows: axial and coronal two dimensional T1 weighted fat saturated gradient echo sequences using TR 150 msec, TE 2. 1 msec, 160 × 256 matrix, 20 slices, 5 mm thickness, and 0 mm interslice gap. For the measurement of tumor burden and diameter of tumor thrombus in portal vein, postcontrast T1 weighted images were applied. CE MRI CE MRI of the liver was performed using a phased array body coil on the same 1. 5 T MRI system using the following protocol. A total of 0. 1 mmol kg body weight of gadolinium diethylenetriaminepentaacetic acid contrast media was power injected at 2 mL sec, followed by a saline chase of 20 mL at a rate of 2 mL sec.

The arterial, portal and delayed phase scanning were performed after 35, 65 and 280 seconds from the initiation of contrast medium bolus. Three dimensional volume interpolated excitation axial T1 sequence was obtained LY2109761 in a breath hold after con trast media injection using the following parameters: TR 5 msec, TE 1. 58 msec, 5 mm slice thickness, 0 mm interslice gap, 20 slices, 123 × 192 matrix, and field of view of 400 × 400 mm. Data were processed at a picture archiving and communi cation system by two experienced radiologists with 13 and 10 years of experience in liver imaging. To obtain permeability maps, MRP images were processed at pixel resolution by using a commercially available full time point model to analyze the time evolution of contrast enhancement.

Tumor size was measured in the longest cross sectional dimension for each lesion based on RECIST 1. 1 guidelines. And viable tumor diameter was measured in the longest cross sectional dimension for enhancing component of each lesion based on mRECIST guidelines. The sum of the longest dimensions of selected target lesions in each pa tient was computed, and the absolute and percent changes of the sum from the baseline to post treatment evaluation were computed for each patient. Diagnostic standard and diameter measurement for tumor thrombus in portal vein was referred to the criteria described by Shah et al, The apparent diffusion coefficient map was auto matically generated on the imager console from the DWI sequence; the selected b values were used for ADC quantification.