Correlation of PDGFR and PDGFRB genetic variants and clinicopathological featur

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 Correlation of PDGFR and PDGFRB genetic variants and clinicopathological featur Empty Correlation of PDGFR and PDGFRB genetic variants and clinicopathological featur

Post  jy9202 on Fri Feb 21, 2014 6:41 am

Previous studies demonstrated that SDHB, SDHC, and SDHD related paragangliomas and GIST all show loss of SDHB immunohistochemical e pression, It was suggested that absence of functional SDHC or SDHD leads to im pairment of comple II formation purchase KU-55933 and degradation of SDHB. Our results, showing absence of SDHB e pression in SDHA mutated GIST, are in accordance with this e planation. In contrast, whereas SDHB e pression was not detected in all WT GIST included in our series, all these tumors displayed e pression of SDHA. These findings sug gest that the SDHB protein is degraded when the succin ate dehydrogenase comple II is disrupted, whereas the SDHA protein remains intact.

By pooling our results with those of previous studies, it appears that Linifanib 796967-16-3 the majority of mutations of genes encoding subunits of the SDH comple II iden tified in apparently sporadic KIT and PDGFRA WT GIST occurred in young adults, However, the majority of sporadic or syndromic KIT and PDGFRA WT GIST, occurring in the pediatric or young adult setting, display loss of SDHB protein, suggest ing that defects in cellular respiration is a crucial event even in cases without mutation of the succinate de hydrogenase comple II. Therefore, further investigation are needed to identify the mechanism involved in the al teration of the succinate dehydrogenase comple II func tion in cases without mutation of SDHA, B, C or D. Conclusion In conclusion, this study provides additional evidence that SDHA is another important gene involved in the tumorigenesis of a subset of GISTs lacking KIT or PDGFRA mutation.

Although the number of identified mutation carriers is still low, current observations sug gest that mutations of the succinate dehydrogenase com ple II are more particularly associated with KIT and PDGFRA WT GIST occurring LY3009104 in young adults, outside the Carneys triad trait. Although pediatric GIST consist ently display alterations of SDHB protein e pression, further molecular studies are needed to identify the cru cial genetic events involved in their tumorigenesis. Gen etic screening for SDHB, C and D germline mutations is recommended for patients with paraganglioma pheo chromocytoma and SDH deficient GISTs. At the time of this writing, it remains uncertain whether patients with SDHA deficient GIST are also at increased risk for the tumors associated with SDH germline mutation.

The penetrance of SHDA mutations is also unknown. There fore, further investigations are needed to clarify the clinical significance of a SDHA germline mutation and its impact in terms of genetic counseling. Colorectal cancer is the third most common tumour in the world, with over 1. 2 million new cases diagnosed every year, and is responsible for about 8% of cancer related deaths, Appro imately one third of patients present metastatic disease at diagnosis, and about 40% of those with early stage tumors will eventu ally relapse at some point over the course of the disease, Although prognosis has greatly improved over the past decades due to significant surgical and medical advances, once the tumor has progressed beyond surgi cal resectability, the disease is essentially incurable and median survival ranges from 14 to 24 months with best available systemic therapy, Development of new more effective agents is thus actively pursued.


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